Presenting breast cancer in 5%to 10%.of cases in economically developed countries 20%to25% of case world wid. Heterogeneous group of diseases include T3_T4 cancer. Localy advanced breast cancer carcinoma right breast cancer tumour measures 5cm breast extend chest wall or skin ipsilateral nodes or insilateral interal mammary nodes diseases stage 3A (t3,N,Or any N2) initially inoperable stage 3B any N3 or any T4