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EST has
been shown to affect most phases of wound healing including
inflammation, proliferation and remodelling . In vitro studies
have demonstrated that EST can: induce fibroblastic activity by
increasing DNA and protein synthesis as well as calcium
influx promote migration and activation of macrophages
and promote myofibroblast transdifferentiation Furthermore, in vivo studies have demonstrated that EST can:
enhance angiogenesis by increasing capillary density, improve
tissue oxygenation through increased blood flow
and improve tissue tensile strength by increasing collagen deposition . In addition, researchers have suggested that
EST has both bacteriostatic and bactericidal effects on microbes
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