Top 8 Interesting Off-Label Medicine Uses! 1. Colchicine - pericarditis 2. Clonidine - opioid withdrawal 3. Naltrexone - compulsive gambling 4. Prazosin - nightmares 5. Topiramate - weight gain 6. Memantine - OCD 7. Modafinil - depression 8. Propanolol - thyrotoxicosis