Dr. Fatemeh Kourkinejad

over 5 years ago

Peroxisome proliferator–activated receptor γ (PPARγ) is a transcription factor that regulates genes involved in energy metabolism. PPAR-gamma decreases the inflammatory response of many cardiovascular cells, particularly endothelial cells. PPAR-gamma activates the PON1 gene, increasing synthesis and release of paraoxonase 1 from the liver, reducing atherosclerosis.