Biochemistry Question 01: A 45-year-old man presents to his physician for chronic arthritis, which is worsening and affecting his lower back, hips, and knees. On physical examination, you notice that the patient’s sclerae appear to have a brown discoloration; however, his vision is unchanged from prior examinations. His ear cartilage is similarly discolored. An x-ray of the spine reveals disk degeneration and dense calcification that is most prominent in the lumbar region. His urine appears normal at first but begins to darken with time. What is your diagnosis?