Sarahover 1 year ago

Clinical Uses of Tissue Plasminogen Activator (tPA)

Tissue plasminogen activator (tPA) converts plasminogen into plasmin, then plasmin will dissolve the fibrin clot into degradation produts “i.e. fibrinolysis”. This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding). There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc).