Testicular
A 29-year-old man complains of a vague feeling of painless heaviness in the scrotum for the past 5 months. He is otherwise healthy. Physical examination shows that the right testis is slightly larger than the left testis. An ultrasound scan shows a solid, circumscribed, 1.5-cm mass in the body of the right testis. The representative gross appearance of the mass is shown in the figure. A biopsy is done, and microscopic examination of the mass shows uniform nests of cells with distinct cell borders, glycogen-rich cytoplasm, and round nuclei with prominent nucleoli. There are aggregates of lymphocytes between these nests of cells. Which of the following features is most characteristic of this lesion? A. Association with 46,X(fra)Y karyotype B. Association with 46,XXY karyotype C. Response to radiation therapy D. Extensive pulmonary metastases E. Elevation of human chorionic gonadotropin level F. Elevation of α-fetoprotein level . Seminoma Age: 30-35 years; >65 Seminoma is a malignant tumor comprised of large cells with clear cytoplasm and central nuclei (resemble spermatogonia) Yellow tumor usually without significant hemorrhage or necrosis. Most common testicular tumor; resembles ovarian dysgerminoma Prognosis: Excellent. Extremely radiosensitive. Elevation of human chorionic gonadotropin level in 10% of cases.
