Fig 52-year-old man with chronic hepatitis C without evidence of fibrosis at liver biopsy (stage F0; top) and 67-year-old woman with cirrhosis secondary to chronic hepatitis C (stage F4; bottom). Single-Shot Echo-Planar Diffusion-Weighted Image (SS-EPI DWI) with b = 700 (left) mm2/s and apparent diffusion coefficient (ADC) map (right) (using b = 0 and 700 mm2/s) are shown. In patient without fibrosis, hepatic ADC was within normal range, measuring 1.6 × 10−3 s/mm2, with liver appearing brighter than spleen (which is known to have low ADC). In patient with fibrosis, hepatic ADC was decreased, reaching spleen ADC, measuring 1.0 × 10−3 s/mm2 (Taouli et al. 2009). Bi-exponential models (eg IVIM) may provide better results due to the high vascularity of liver tissue.