Biochemical_MRI methods have been introduced successfully in the clinical practice to address limitations of #morphological_MRI in the field of early detection of degenerative cartilage disease. T1rho maps (first row) and T2 maps (second row) for a healthy control (a), a patient with mild #OA (b), and a patient with severe OA (c). The maps illustrate the differences between T1rho and T2 and demonstrate differences in cartilage heterogeneity between OA severity and between T2 and T1rho maps.