DWI with readout-segmented EPI (#RESOLVE) is a multi-shot EPI sequence where the k-space trajectory is divided into multiple segments in the readout direction, reducing TE and encoding times to increase image quality. The sequence provides high-quality, high-resolution, distortion-minimized #DWI of challenging body regions, including the skull base, spine, breast, pelvis and MSK. High-resolution #DTI can also be achieved for the brain and spine. Imaging can be performed in all orientations and the sequence is compatible with parallel imaging, providing a further reduction in susceptibility-based distortions. #MRI