Medshotsover 1 year ago

Cleft lip

Shown here is an infant born with cleft lip.Cleft lip is an embryological defect, it occurs in 1:1000, more common in males. Of the known 200 syndromes associated with cleft lip and palate, van der Woude syndrome is the most common. Risk factors are alcohol, tobacco, phenytoin, and retinoic acid. The pathophysiology behind this is maxillary and medial nasal prominences fail to fuse together resulting in the characteristic persistent labial groove (cleft lip). By the 18th week of the embryo we can do prenatal ultrasound which can diagnose the condition. Primary treatment is surgical correction.