Anas Abubakaralmost 6 years ago

16 Therapeutic action – Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID) Indications – Mild pain – Fever – Rheumatic diseases (except gout) Presentation – 100 mg and 500 mg tablets. Also comes in 300 mg tablets. Dosage – Pain and fever Child: 60 mg/kg/day in 3 or 4 divided doses Adult: 1 to 3 g/day in 3 or 4 divided doses – Rheumatic diseases Child > 20 kg: 50 to 100 mg/kg/day in 4 divided doses Adult: 3 to 6 g/day in 4 divided doses – Maximum dose: child: 100 mg/kg/day; adult: 6 g/day Duration: pain and fever: 1 to 3 days; rheumatic diseases: according to clinical response. Contra-indications, adverse effects, precautions – Do not administer to patients with allergy to aspirin and NSAID, peptic ulcer, coagulation disorders, haemorrhage; severe renal, hepatic or cardiac impairment. – Do not administer to children under 1 year (use paracetamol). – Administer with caution to elderly patients or patients with asthma. – Do not exceed indicated doses, particularly in children and elderly patients. Intoxications are severe, possibly fatal. – May cause: • allergic reactions, epigastric pain, peptic ulcer, haemorrhage; • dizziness, tinnitus (early signs of overdose). For all cases above, stop aspirin and use paracetamol. – Do not combine with methotrexate, anticoagulants and NSAID. – Monitor combination with insulin (increased hypoglycaemia) and corticosteroids. – Pregnancy: not recommended during the first 5 months; CONTRA-INDICATED from the beginning of the 6th month (use paracetamol) – Breast-feeding: avoid (use paracetamol) Remarks – In children less than 16 years, preferably use paracetamol. – Take during meals, preferably with a lot of water. – For the treatment of moderate pain, it is recommended to combine aspirin with codeine or tramadol. – Aspirin may be administered for its antiplatelet effects in secondary prevention of athero- thrombosis, at a dose of 75 to 300 mg daily. – Storage: below 25°C – Do not use if tablets have a strong smell of vinegar. A slight vinegar smell is always present. ACETYLSALICYLIC acid = ASPIRIN = ASA AGE WEIGHT 0 2 months 1 year 5 years 4 kg 8 kg 15 kg 35 kg 100 mg tablet – – 1 1/2 tab x 3 3 tab x 3 – 300 mg tablet – – 1/2 tab x 3 1 tab x 3 2 tab x 3 500 mg tablet – – 1/4 tab x 3 1/2 tab x 3 1 tab x 3 ADULT 15 years.