some common causes of an enlarged spleen: Infections Viral infections, such as mononucleosis Parasitic infections, such as toxoplasmosis Bacterial infections, such as endocarditis (an infection of your heart's valves) Cancer Leukemia, a cancer in which white blood cells displace normal blood cells Lymphoma, a cancer of lymph tissue, such as Hodgkin's disease Other causes of an enlarged spleen include: Inflammatory diseases such as sarcoidosis, lupus, and rheumatoid arthritis Trauma, such as an injury during contact sports Cancer that has spread (metastasized) to the spleen A cyst, a noncancerous fluid-filled sac A large abscess, a pus-filled cavity usually caused by a bacterial infection Infiltrative diseases such as Gaucher's disease, amyloidosis, or glycogen storage diseases
Chronic myeloid leukemia ,Myelofibrosis, Gaucher disease ,Lymphoma, kalaazar