Which of the following is/are not true about platelets?
ExplanationWhile there is research dedicated to elucidating novel receptors of platelet aggregation, the glycoprotein IIb/IIIa receptor is responsible for a large component of aggregation (as opposed to activation with thromboxane A2). In experiments of a porcine model lacking vWF, initial contact adhesion was not affected. However, activation of platelets was dependent on soluble vWF. It is thought that it is the soluble vWF that attaches to damaged and exposed subendothelium, slowing the platelets enough to allow attachment principally via the glycoprotein IIb/IIIa receptor.
