Impact of Alcohol + Obesity on Cirrhosis
How Alcohol + Obesity Combined Impact Cirrhosis Alcohol intake and obesity are independent risk factors for morbidity among patients with cirrhosis, but the two factors do not appear to combine for a stronger effect (supra-additive), according to conclusions from a new analysis of participants in the UK Biobank study published in Hepatology and reviewed on Medscape (tap link in bio for full report.) Overall, harmful drinking was associated with 5.0 times the 10-year cumulative incidence of cirrhosis morbidity among harmful versus safe drinkers. However, among those with a healthy BMI, harmful was associated with an 8.6-fold increase of cirrhosis morbidity, compared with safe drinkers . On the other hand, obese patients with harmful drinking habits had a 3.6-fold increase over obese safe drinkers. When looked at according to BMI, 10-year cumulative incidence was 3.1 times higher in patients who with obesity versus those who with healthy BMI. This varied with drinking status. Safe drinkers who with obesity had 3.7 times the incidence, compared with safe drinkers with healthy BMI , and harmful drinkers who were obese had a 1.4-fold increased incidence, compared with harmful drinkers of a healthy weight. In summation, the researchers found that In contrast to some previous studies, there is little evidence that obesity and drinking interacted supra-additively to modulate the risk of cirrhosis morbidity.
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