MEDizzy
MEDizzy
Su
Suabout 6 years ago
Liver

Liver

A 50-year-old man has increasing dyspnea with idiopathic pulmonary fibrosis, which was diagnosed 18 months ago. Physical examination shows elevated jugular venous pressure and pedal edema. Laboratory studies show serum AST of 221 U/L, ALT of 234 U/L, alkaline phosphatase of 48 U/L, lactate dehydrogenase of 710 U/L, total bilirubin of 1.2 mg/dL, albumin of 3.5 g/dL, and total protein of 5.4 g/dL. The figure shows the microscopic appearance of a liver biopsy specimen. Which of the following terms best describes these findings? A. Apoptosis B. Centrilobular congestion C. Cholestasis D. Hemosiderin deposition E. Macrovesicular steatosis F. Mallory-Denk bodies G. Portal fibrosis #usmlestep1 #usmle #medicine <Credit: Robbins and Contran Review of Pathology> . πŸ™ŒπŸ» β€”οΏ½β€”οΏ½β€”οΏ½β€”οΏ½ ✍🏻 . Answer: The microscopic appearance is that of intense centrilobular congestion. The area around the portal tract is less congested. The restrictive lung disease leads to cor pulmonale with right-sided congestive heart failure. This causes passive venous congestion in the liver that is most pronounced in the centrilobular areas. When congestion is severe, the anoxia can cause centrilobular necrosis with transaminanse elevation

8
Other commentsSign in to post comments. You don't have an account? Sign up now!
about 6 years ago

CVC

about 6 years ago

E

Recent MCQs

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ
Show more MCQs

Recent flashcard sets

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ

β€Œ
β€Œ
Show more flashcards